Eczema herpeticum is a rare but severe disseminated infection that generally occurs at sites of skin damage produced by, for example, atopic dermatitis, burns, long term usage of topical steroids or eczema. It is also known as Kaposi varicelliform eruption, Pustulosis varioliformis acute and Kaposi-Juliusberg dermatitis.
Eczema herpeticum (EH) 是由單純皰疹病毒在異位性皮膚炎患者中引起的廣泛皮膚感染。它通常突發,於濕疹易發部位出現水皰樣水皰、糜爛並結痂。患者可能出現發燒、淋巴結腫大或全身不適。健康成人的 EH 可能僅為輕度、短暫,但在兒童、嬰兒及免疫功能低下者中,病情可非常嚴重。及早開始抗病毒治療可縮短輕症病程,並降低重症併發症的風險。 Eczema herpeticum (EH) is a disseminated cutaneous infection with herpes simplex virus that develops in a patient with atopic dermatitis. EH typically presents as a sudden onset eruption of monomorphic vesicles and punched-out erosions with hemorrhagic crusts over eczematous areas. Patients may have systemic symptoms, such as fever, lymphadenopathy, or malaise. Presentation ranges from mild and self-limiting in healthy adults to life-threatening in children, infants, and immunocompromised patients. Early treatment with antiviral therapy can shorten the duration of mild disease and prevent morbidity and mortality in severe cases.
一名 8 歲、患有異位性皮膚炎的女孩來院時,身上出現大面積發癢且凸起的紅色水泡,水泡中央有一個小凹痕。檢驗結果顯示她感染了第一型單純皰疹病毒。 An 8-year-old girl with atopic dermatitis came in with a widespread outbreak of itchy, raised, red blisters with a small indentation in the center. Tests showed she had herpes simplex virus type 1.
此感染的臨床表現為在異位性皮膚炎上疊加大量水泡,常伴發燒與淋巴結腫大。疱疹性濕疹可能危及嬰兒生命。
大多數病例由單純皰疹病毒引起,可使用全身性抗病毒藥物治療,例如 acyclovir(阿昔洛韋)。
○ 診斷與治療
若誤將其診斷為一般濕疹(如異位性皮膚炎)而使用類固醇軟膏,可能會加重皮損。
#Acyclovir
#Fancyclovir
#Valacyclovir